Compliance with Schedule M of the Drugs and Cosmetics Act (2018)

In a recent announcement, Health Minister Mansukh Mandaviya emphasized the importance of complying with Schedule M of the Drugs and Cosmetics Act, prepared in 2018. A Pharma company with a turnover of less than Rs 250 crore will have to adopt GMP regulations in a 12-month time, and those with over Rs 250 cr turnover must have GMP adoptions within 6 months.

The schedule outlines crucial guidelines for all the Organizations manufacturing drugs may be Pharmaceutical, Biotech, Therapeutics, and CROs must comply with Schedule M automation. However, non-compliance with the stipulated timelines could lead to penalties as per the provisions of the law. Also, the most significant gap found in the industry is the Linkage between manufacturing and product quality, and interdependence between the two has been established.

Understanding Schedule M

Schedule M delves into various aspects of company premises, quality control systems, laboratories, GMP adoption in production, equipment cleaning, housekeeping, and cross-contamination. Organizations involved in drug manufacturing must adhere to these guidelines for maintaining high-quality standards.

Implementing Schedule M Automation in Organizations

Compliance with Schedule M demands a coordinated effort across different departments, including Production, Engineering, Quality Control, Quality Assurance, and Warehouse. Many small and medium-sized organizations manage these activities manually, leading to potential compliance issues like GMP regulations.

Challenges Faced by Small and Medium Enterprises

Even with stringent processes, human error can still lead to compliance challenges. Moreover, implementing automation systems demands a considerable budget and skilled talent, which might only be readily available to some enterprises.

How do we link between manufacturing and product quality and interdependence?

Organizations can leverage cost-effective integrated software to bridge the manufacturing and product quality gap. These systems include:

  1. ERP: For comprehensive management of procurement, inventory, and sales processes.
  2. LIMS: To streamline laboratory quality control procedures.
  3. eQMS with RTM: For automating deviations, CAPA (Corrective and Preventive Actions), change control, and audits in the quality assurance department.
  4. eDMS: To automate version control and print management of SOPs, protocols, specifications, and more across all departments.
  5. eLMS: For efficient management of training processes throughout the organization.
  6. eBMR (MES): To handle batch manufacturing information effectively.
  7. eLog Book: For recording operational and cleaning activities in operations.
  8. APQR: For automated product quality report generation based on integrated software data.
  9. RIMS: To track regulatory application statuses from filing to retirement.
  10. Calibration and PM: The engineering department can manage assets in compliance with guidelines set forth by the schedule.
Integrated Solutions scaled

Pharma automation companies like Amplelogic help in the current timebound scenarios

Amplelogic can play a pivotal role in the timely implementation of automation solutions. With over 13 years of experience delivering automation software for Drug Product and Drug substance organizations, Amplelogic offers ready-to-use software that can be swiftly implemented. The implementation timelines can be tailored within 1 to 3 months, depending on the scope.

Conclusion

Compliance with Schedule M is a crucial aspect of the pharmaceutical industry. Embracing automation and integrated software can help organizations, especially small and medium enterprises, overcome compliance challenges and achieve seamless adherence to Schedule M automation, ultimately enhancing product quality and patient safety.

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Root Cause Analysis with example for “5” Why technique

Root Cause Analysis (RCA) is a method that is used to address a problem or non-conformance in the quality process to get to the “root cause” (actual cause of origin) of the non-conformity. RCA helps to correct or eliminate the cause and prevent the problem from recurring (preventive action). Root cause analyses is aimed at improving products or processes quality and must an in systematic ways to be effective. Different Methods of doing Root Cause Analysis: Root Cause Analysis Methodology   Fish bone technique The “5” Why’s technique. Barrier Analysis Change Analysis Casual Factor tree analysis Failure mode and effects analysis Pareto analysis Advantages: To identify non-conformity and the causes, so that permanent solution can be found. To develop a logical approach of problem-solving, using data that already exists in QMS (Quality Management System) To identify current and also future needs for organizational quality improvement. To establish a repeatable systematic step by step processes, in which one process can confirm the results of another with deep analysis. Challenges: Not having the ability to understand the problem and therefore not defining it correctly. Not considering all possible failure modes. Not able to identify all root causes. No proper defined solution for the non-conformity. The “5” Why technique causes mapping Non-conformity identified: Decrease in the viscosity of Vitamin D3 syrup. The “5” why technique can be expanded to 15 why or 150 why the deeper you go the more thorough analyzing takes place and reveals better solutions Contact us for more information about the AmpleLogic Quality Systems Offerings.   Schedule a Free Consultation Request a Demo First NameLast NameCompany NameEmailPhone NumberDesignationCountrySelect CountryAfghanistanAland IslandsAlbaniaAlgeriaAmerican SamoaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelauBelgiumBelizeBeninBermudaBhutanBoliviaBonaire, Saint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBritish Virgin IslandsBruneiBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCook IslandsCosta RicaCroatiaCubaCuraçaoCyprusCzech RepublicDemocratic Republic of the Congo (Kinshasa)DenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland IslandsFaroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuamGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and McDonald IslandsHondurasHong KongHungaryIcelandIndiaIndonesiaIranIraqIrelandIsle of ManIsraelItalyIvory CoastJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKosovoKuwaitKyrgyzstanLaosLatviaLebanonLesothoLiberiaLibyaLiechtensteinLithuaniaLuxembourgMacao S.A.R., ChinaMacedoniaMadagascarMalawiMalaysiaMaldivesMaliMaltaMarshall IslandsMartiniqueMauritaniaMauritiusMayotteMexicoMicronesiaMoldovaMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorth KoreaNorthern Mariana IslandsNorwayOmanPakistanPalestinian TerritoryPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalPuerto RicoQatarRepublic of the Congo (Brazzaville)ReunionRomaniaRussiaRwandaSaint BarthélemySaint HelenaSaint Kitts and NevisSaint LuciaSaint Martin (Dutch part)Saint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia/Sandwich IslandsSouth KoreaSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyriaTaiwanTajikistanTanzaniaThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited Kingdom (UK)United States (US)United States (US) Minor Outlying IslandsUnited States (US) Virgin IslandsUruguayUzbekistanVanuatuVaticanVenezuelaVietnamWallis and FutunaWestern SaharaYemenZambiaZimbabweWhere you heard about us?– Select –Google SearchLinkedInReferralWord of MouthLinkedIn AdsMediumRequirementGet in touch

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Why is embracing the Document Management System still intimidating?

DMS in a layperson perception A thorough-cum-simpler explanation of Document Management System will make us understand about the efficacy of this digital trend. With the name “Electronic Document Management System”, we get an overall idea that the system is supposedly managing the documentation process. Now, this process is the common one being done in every organization, we all know. Here the point comes is : How are these documentation things being processed or managed in various industries these days? Collecting all the needed data or information of a company and putting them down in a specific file or document is something that we know very well, which has been done manually for ages. But with trending technological inventions like IoT, AI, Cyber Security, etc., in the ongoing digital world, we must step up to a more effort-less mode of documentation. So, with this, we came up with eDMS.  Replacing manual documentation work to automated-cum-electronic documentation, Electronic Document Management System has brought a different level of changes in contemporary pharma as well as life sciences companies. A quick peek of digitalization using Electronic Document Management Software (eDMS) While DMS has given us chances to ease our pain with an effective modification in documentation tasks, FDA’s 21 CFR part 11 has confirmed that electronic documents along with the records and signatures can surely be considered as the legitimate ones. Hence, it has confirmed that there will be no difference between paper signature and e-signature, rather the later one will be more considerable. Let’s have a quick walk through the benefits we have gained with Electronic Document Management System in contemporary pharma companies. Easy creation, management, and storage of all the crucial data and information of the company is possible with DMS. On incorrect data feeding, mismatch of information, missing data, you will get a reminder or notification which is not possible in manual management. All the data is stored in a specific and common cloud, which is accessible to everyone from everywhere. A smooth documentation now ensures a streamline workflow and saves a lot of time and resources which can be used in other areas of growth. Complete replacement of paperworks into paperless documentation becomes easy with eDMS. Having thorough data on drugs, research, new compliances, regulations require error-free documentation and with Pharmaceutical Document Management Solution this task can be managed easily. Storage of all the digital documents under a common cloud is much safer than keeping manual data in the form of documents stored in some physical storage. Accessible cloud storage documentation allows you to access the data whenever and wherever required, whereas in manual management there is some chance of missing out on important data. An organized documentation not only takes care of the data storage but also ensures a smooth flow of additional departments like SOP Management, manufacturing, operation, quality planning, etc. Terrorizing reasons restricting full-fledged eDMS inculcation Despite a lot of benefits, there are many companies who are reconsidering their decisions of incorporating Document Management Systems into their business. Every innovation comes with certain pros and cons. When we have already understood several benefits of the automatic documentation process, let’s explore the risky or stressed side or probable challenges of this digital trend. Data being vulnerable: With documentation being staged on digital platforms, it is extremely necessary to keep an eye on the security side. When crucial data is stored in the cloud then there comes a major terror of data being vulnerable and being attacked by malicious cyber frauds. Hence, it is required to maintain utmost cybersecurity ensuring the documentation is safe in the cloud kept away from cyber thefts. Doubt on successful implementation: There are so many growing features of Electronic Document Management and Tracking Software for Lifesciences industries, but we need to explore all those specifications accurately. Adding on a digital trend to a business could sound fun, but the real game starts when you implement the software effectively. This can be done with active seminars, group discussions, and taking feedback from employees (who are using it) on document management solution. Fear of smooth integration: The DMS must come up with appropriate integration of all relevant departments, then only we can assure its potential usage. Hence integration of DMS with other in-house applications must be done properly to make the system work automatically and independently. Staying inconsistent in usage: To replace paperworks with digital paperless ones, giving employees detailed training on Pharmaceutical Document Management and Tracking Software is essential. Hence, keeping the usage of DMS consistent becomes a tough task if the users are not well-trained. So, the prior task is to train employees about the usage of the platform and bring consistency in keeping the system in work consistently. Realising the probable challenges as well as conquered benefits of Document Management Solution we can easily understand how to proceed with this amazing transformation from loads of paper-based documents to hassle-free paperless one-stop-data centres. AmpleLogic’s best DMS software is assisting several pharma as well as other businesses to successfully implement this amazing digital tweak to their work processes making lives easier. Talk to our team to enroll for a free demo on Electronic Document Management System. Schedule a Free Consultation Request a Demo First NameLast NameCompany NameEmailPhone NumberDesignationCountrySelect CountryAfghanistanAland IslandsAlbaniaAlgeriaAmerican SamoaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelauBelgiumBelizeBeninBermudaBhutanBoliviaBonaire, Saint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBritish Virgin IslandsBruneiBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCook IslandsCosta RicaCroatiaCubaCuraçaoCyprusCzech RepublicDemocratic Republic of the Congo (Kinshasa)DenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland IslandsFaroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuamGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and McDonald IslandsHondurasHong KongHungaryIcelandIndiaIndonesiaIranIraqIrelandIsle of ManIsraelItalyIvory CoastJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKosovoKuwaitKyrgyzstanLaosLatviaLebanonLesothoLiberiaLibyaLiechtensteinLithuaniaLuxembourgMacao S.A.R., ChinaMacedoniaMadagascarMalawiMalaysiaMaldivesMaliMaltaMarshall IslandsMartiniqueMauritaniaMauritiusMayotteMexicoMicronesiaMoldovaMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorth KoreaNorthern Mariana IslandsNorwayOmanPakistanPalestinian TerritoryPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalPuerto RicoQatarRepublic of the Congo (Brazzaville)ReunionRomaniaRussiaRwandaSaint BarthélemySaint HelenaSaint Kitts and NevisSaint LuciaSaint Martin (Dutch part)Saint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia/Sandwich IslandsSouth KoreaSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyriaTaiwanTajikistanTanzaniaThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited Kingdom (UK)United States (US)United States (US) Minor Outlying IslandsUnited States (US) Virgin IslandsUruguayUzbekistanVanuatuVaticanVenezuelaVietnamWallis and FutunaWestern SaharaYemenZambiaZimbabweWhere you heard about us?– Select –Google

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Benefits of Training Management System

Here’s what a Training Management System can, and should, do for you: Learning Management System makes it very easy for trainers to update existing training content or add new content in a short time Comply and Meet essential regulatory requirements and other best practices more easily Enhance managers and employees ability to achieve required results, not just complete the training Measure the reduction in operational expenses, travel time and on-site visits Reduce the time for needed for creating, updating, printing and shipping of learning course manuals and documentation Dramatically reduce the cost of software for managing and creating training courses Improve the administration of your learning programs Increase your ability to manage and deploy e-learning to your employees across any location Consolidates training information to improve efficiency, improved facilities coordination and cost utilization Improve personnel performance by enabling you to manage admiration and human resources more effectively Implement more and more effective skills and competency training management programs Reduce training costs Increase the number of training courses that you can deliver for less money Training Course materials on an effectively deployed Learning Management System (LMS) can be accessed by employees across geographies, without affecting the quality or consistency of training These training systems allow the creation, personalization, and download of detailed training reports outlining the progress of the learners, departmental groups, completion of work, time taken to complete the task, etc. which allows easy evaluation of their progress either as an individual or a group A modern Learning Management System, like AmpleLogic LMS, can support your organizations as it grows, and give you the flexibility to add the latest features and functionality to support your training and learning programs Are you ready to invest in a new Learning Management System or LMS? Contact us today to find out more or schedule a demo. Schedule a Free Consultation Request a Demo First NameLast NameCompany NameEmailPhone NumberDesignationCountrySelect CountryAfghanistanAland IslandsAlbaniaAlgeriaAmerican SamoaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelauBelgiumBelizeBeninBermudaBhutanBoliviaBonaire, Saint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBritish Virgin IslandsBruneiBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCook IslandsCosta RicaCroatiaCubaCuraçaoCyprusCzech RepublicDemocratic Republic of the Congo (Kinshasa)DenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland IslandsFaroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuamGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and McDonald IslandsHondurasHong KongHungaryIcelandIndiaIndonesiaIranIraqIrelandIsle of ManIsraelItalyIvory CoastJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKosovoKuwaitKyrgyzstanLaosLatviaLebanonLesothoLiberiaLibyaLiechtensteinLithuaniaLuxembourgMacao S.A.R., ChinaMacedoniaMadagascarMalawiMalaysiaMaldivesMaliMaltaMarshall IslandsMartiniqueMauritaniaMauritiusMayotteMexicoMicronesiaMoldovaMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorth KoreaNorthern Mariana IslandsNorwayOmanPakistanPalestinian TerritoryPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalPuerto RicoQatarRepublic of the Congo (Brazzaville)ReunionRomaniaRussiaRwandaSaint BarthélemySaint HelenaSaint Kitts and NevisSaint LuciaSaint Martin (Dutch part)Saint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia/Sandwich IslandsSouth KoreaSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyriaTaiwanTajikistanTanzaniaThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited Kingdom (UK)United States (US)United States (US) Minor Outlying IslandsUnited States (US) Virgin IslandsUruguayUzbekistanVanuatuVaticanVenezuelaVietnamWallis and FutunaWestern SaharaYemenZambiaZimbabweWhere you heard about us?– Select –Google SearchLinkedInReferralWord of MouthLinkedIn AdsMediumRequirementGet in touch

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